Sara Ramirez's Callie left after Grey’s Anatomy season 12 — here's why. The medical drama series has seen many, many characters leave for different reasons that range from behind-the-scenes troubles to simply wanting to try other projects. Among those is Callie Torres, played by Sara Ramirez, who left the series after season 12 in 2016. Created by Shonda Rhimes, Grey’s Anatomy debuted on ABC in 2005 as a mid-season replacement, but it was so well-received that it has lived on for over ten seasons with many cast changes.
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